منابع مشابه
Assembly chaperones: a perspective.
The historical origins and current interpretation of the molecular chaperone concept are presented, with the emphasis on the distinction between folding chaperones and assembly chaperones. Definitions of some basic terms in this field are offered and misconceptions pointed out. Two examples of assembly chaperone are discussed in more detail: the role of numerous histone chaperones in fundamenta...
متن کاملHistone Chaperones in the Assembly and Disassembly of Chromatin
Nucleosomes physically block access to the DNA, raising several questions (1) How are new nucleosomes formed in vivo? (2) How are nucleosomes removed to facilitate DNA templated processes? and (3) How are histones restored to the DNA following the completion of those processes? The intrinsic attraction between the negatively charged DNA phosphate backbone and the positively charged lysine and a...
متن کاملMutant DnaK chaperones cause ribosome assembly defects in Escherichia coli.
To determine whether the biogenesis of ribosomes in Escherichia coli is the result of the self-assembly of their different constituents or involves the participation of additional factors, we have studied the influence of a chaperone, the product of the gene dnaK, on ribosome assembly in vivo. Using three thermosensitive (ts) mutants carrying the mutations dnaK756-ts, dnaK25-ts, and dnaK103-ts,...
متن کاملChaperones involved in assembly and export of N-oxide reductases.
Controlled targeting and transport of redox enzymes to and across the bacterial cytoplasmic membrane is essential for bacterial respiration. A subset of bacterial redox enzymes is exported as folded proteins on the Tat (twin-arginine transport) pathway. Protein export is the point-of-no-return for passenger proteins on the Tat pathway and it is crucial that complex, cofactor-containing enzymes ...
متن کاملPeriplasmic Chaperones—Preservers of Subunit Folding Energy for Organelle Assembly
The periplasmic PapD-like chaperones have long been known to be necessary for the assembly of bacterial surface organelles. New structural work now suggests that they control assembly by arresting subunit folding. This step may be required to preserve energy for fiber formation.
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ژورنال
عنوان ژورنال: Philosophical Transactions of the Royal Society B: Biological Sciences
سال: 2013
ISSN: 0962-8436,1471-2970
DOI: 10.1098/rstb.2011.0398